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Featured Application Notes Conformational Characterization of Calmodulin by Hydrogen Deuterium Exchange Mass Spectrometry Joomi Ahn, Martha Stapels, Michael Eggertson, Keith Fadgen, and Ying Qing Yu, Waters In this work, we determine changes in conformation in bovine calmodulin (apo and holo) that occur upon calcium binding using high-resolution hydrogen deuterium exchange mass spectrometry (HDX). Waters HDX Technology facilitates the sturdy of protein conformation and protein dynamics at global and local levels to help researchers understand protein function and related biological activity. Sanitization and endotoxin clearance in AxiChrom columns GE Healthcare Studies show that the AxiChrom column design allows operation at high standards of hygiene, as required in cGMP environments, and confirm that 1 M NaOH is an effective clearance/sanitization agent. Physicochemical characterization of a therapeutic protein by peptide mapping, SEC and IEX Srividya Kailasam, Jochen Strassner, and Martin Vollmer, at Agilent Technologies in Bangalore, India, and Waldbronn, Germany; P.M. Sundaram and Bharathi Sriram at GangaGen Biotechnologies Pvt. Ltd in Bengaluru, India Sensitive and rapid LC methods were developed on the new Agilent 1260 Bio-inert LC system to characterize the the rapeutic protein, P128. Optimized peptide mapping with sub-2-µm column technology, size exclusion chromatography (SEC) and ion exchange chromatography (IEX) were performed, to increase separation efficiency for the detection of potential impurities in therapeutic protein preparation. Ion Chromatography Services George Limpert, Celsis International Celsis has added a Dionex ICS-3000 ion chromatographic system. This system determines inorganic anions, cations and organic acids, as well as uses amperometric detection for accurate analysis of traditionally difficult pharmaceuticals. Bio-G Biomanufacturing Webinar Rick Johnston, Ph.D., Bioproduction Group Biopharmaceutical manufacturing equipment and labor are expensive, finite and often shared across multiple processes. In this webinar we will describe the limitations of the today's mostly simplistic Microsoft Project-like scheduling tools and why these result in sub-optimal plans. We will provide real-world examples of a way to schedule biomanufacturing plant operations in real time using Bio-G's Simulation platform, which takes account of the complexity of the process, the finite and shared nature of facility resources, plus the need for split-second re-scheduling. Automatically Detecting, Differentiating Agglomerated Proteins in Parenterals Fluid Imaging This paper explains how counting and characterizing particles based upon their actual size and shape instead of by ESD permits protein agglomerates to be automatically differentiated from silicone droplets, air bubbles and foreign matter. You are subscribed to biopharminternational as honrao.priti.1234@blogger.com. Click here to unsubscribe or edit your member profile To ensure delivery to your Inbox, please add us to your address book. If you need help doing this, click here. Advanstar Communications provides certain customer contact data (such as customers' names, addresses, phone numbers and e-mail addresses) to third parties who wish to promote relevant products, services and other opportunities which may be of interest to you. If you do not want Advanstar Communications to make your contact information available to third parties for marketing purposes, simply call (toll free) 1-866-529-2922 at any time, or fax us at 1-218-740-6417. Outside the U.S., please phone 1-218-740-6395. Contact us by mail at Advanstar Communications Inc., 131 West First St., Duluth, MN 55802-2065, USA.